VIL1 ELISA Kit for Chicken(Gallus gallus) | EIAab.comVIL1 ELISA Kit for Chicken(Gallus gallus)

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Index > Protein center > VIL1(Gene name) > Chicken

VIL1 (Gene name),

Villin-1 (Protein name ), VILI_CHICK from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

VIL1(VIL);

Protein name:

Villin-1;

Alternative:

Organism:

Chicken (Gallus gallus).

General Annotation

Sub Unit:

Monomer. Homodimer (By similarity). Associates with F-actin; the association with F-actin is inhibited by tropomyosin.

Function:

Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol-4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin.

Subcellular Location:

Cytoplasm cytoskeleton Cell projection microvillus Cell projection lamellipodium Cell projection ruffle Cell projection filopodium tip Cell projection filopodium

Protein Attributes:

Sequence length:

826

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

826:

FGMTRSAFAN | LPLWKQQNLK | KEKGLF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00626

UniGene:

Gga.816

STRING:

9031.ENSGALP00000037398

KEGG:

gga:396423

SMR:

P02640

Uniprot:

P02640

FOR

ELISA Kit for Chicken Villin-1

Cat.:

E0193h

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Packing:

96T

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ELISA Kit for Chicken Villin-1

Cat.:

E0193m

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96T

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ELISA Kit for Chicken Villin-1

Cat.:

E0193p

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Manual:

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96T

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ELISA Kit for Chicken Villin-1

Cat.:

E0193c

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96T

ELISA Kit for Chicken Villin-1

Cat.:

E0193b

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Packing:

96T

CLIA Kit for Chicken Villin-1

Cat.:

U0193h

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MSDS:

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Packing:

96T

CLIA Kit for Chicken Villin-1

Cat.:

U0193c

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MSDS:

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Packing:

96T

CLIA Kit for Chicken Villin-1

Cat.:

U0193b

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MSDS:

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Packing:

96T

CLIA Kit for Chicken Villin-1

Cat.:

U0193m

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MSDS:

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Packing:

96T

CLIA Kit for Chicken Villin-1

Cat.:

U0193p

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Packing:

96T

Polyclonal Antibody for Chicken Villin-1

Cat.:

P0193Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Chicken Villin-1

Cat.:

P0193Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Chicken Villin-1

Monoclonal Antibody for Chicken Villin-1

Protein for Chicken Villin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Villin sequence and peptide map identify six homologous domains."
Bazari W.L. , Matsudaira P. , Wallek M. , Smeal T. , Jakes R. , Ahmed Y.
Proc. Natl. Acad. Sci. U.S.A.85:4986-4990(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Demonstration of at least two different actin-binding sites in villin, a calcium-regulated modulator of F-actin organization."
Glenney J.R. Jr. , Geisler N. , Kaulfus P. , Weber K.
J. Biol. Chem.256:8156-8161(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 751-826
3.

"Demonstration of three distinct calcium-binding sites in villin, a modulator of actin assembly."
Hesterberg L.K. , Weber K.
J. Biol. Chem.258:365-369(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CALCIUM-BINDING SITES
4.

"Tropomyosin distinguishes between the two actin-binding sites of villin and affects actin-binding properties of other brush border proteins."
Burgess D.R. , Broschat K.O. , Hayden J.M.
J. Cell Biol.104:29-40(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH F-ACTIN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
5.

"An actin footprint on villin. Single site substitutions in a cluster of basic residues inhibit the actin severing but not capping activity of villin."
de Arruda M.V. , Bazari H. , Wallek M. , Matsudaira P.
J. Biol. Chem.267:13079-13085(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH F-ACTIN;MUTAGENESIS OF ARG-138; HIS-141; GLY-144; LYS-145 AND LYS-146
6.

"Solution structure of villin 14T, a domain conserved among actin-severing proteins."
Markus M.A. , Nakayama T. , Matsudaira P. , Wagner G.
Protein Sci.3:70-81(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-127
7.

"Refined structure of villin 14T and a detailed comparison with other actin-severing domains."
Markus M.A. , Matsudaira P. , Wagner G.
Protein Sci.6:1197-1209(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-127
8.

"NMR structure of the 35-residue villin headpiece subdomain."
McKnight C.J. , Matsudaira P.T. , Kim P.S.
Nat. Struct. Biol.4:180-184(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 792-826
9.

"High-resolution crystal structures of villin headpiece and mutants with reduced F-actin binding activity."
Meng J. , Vardar D. , Wang Y. , Guo H.-C. , Head J.F. , McKnight C.J.
Biochemistry44:11963-11973(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 760-826;MUTAGENESIS OF ARG-787 AND TRP-814
10.

"High-resolution X-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein."
Chiu T.K. , Kubelka J. , Herbst-Irmer R. , Eaton W.A. , Hofrichter J. , Davies D.R.
Proc. Natl. Acad. Sci. U.S.A.102:7517-7522(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.95 ANGSTROMS) OF 792-826

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